Pac-12’s reputation has really been stung with OOC losses, including losses to Hawaii, BYU, etc. Pac-12 has yet to get a marquee OOC win, though Oregon stayed close when playing at Auburn. Notre Dame will be a high profile game this year (usually is, anyway) but a USC win looks like a longshot with USC failing to get any road wins so far, Notre Dame perfect so far at home, and Notre Dame currently a 11-point favorite.
Take Notre Dame to cover. Slovis will be back, he was pretty bad in his only other road start against a below average defense. He’ll be facing a much better defense in this game.
I’d love to see it, but I can’t recall the last time USC defeated anyone of prominence outside of the conference (Rose Bowl in 2016 against Penn St was their last good OOC win).